A sugary hat trick
December 11, 2024 by ferniglab
The Sulfation difficulty of Essays in Biochemistry is out. This has its origins within the glorious September 2023 SUPA 2023 assembly, supported by the Biochemical Society and organised by Jon Mueller and colleagues. All the quantity is price studying, because it covers a number of new floor and concepts, beginning with the sulfate anion itself in physiology by way of to sulfated mobile merchandise.
Our personal contribution was a assessment on the interactions of heparan sulfate with proteins and one on polysaccharide sulfotransferases. It has been 16 years since we wrote a assessment on the primary matter and since there have been substantial advances. We took the chance to construct up from the fundamentals to some new(ish) concepts on the selectivity of those interactions and the way they might management the diffusion of heparan sulfate-binding proteins within the extracellular area. Polysaccharide sulfotransferases are just about terra incognita. They happen throughout the Tree of Life, but nearly all of our knowledge are on the mammalian Golgi enzymes; putative enzymes are the overwhelming majority on this discipline!
In the summertime I began my engagement with Dulce Papy-Garcia’s division in UPEC; my relationship to the division goes again to the mid Nineties and I’ve at all times discovered it to be a most stimulating surroundings. It transpired that her Group had undertaken a large evaluation of the enzymes concerned in heparan sulfate biosynthesis and from that had elaborated an thrilling new speculation concerning its regulation, which amongst different issues defined the counter intuitive phenotypes of a variety of genetic issues. I emailed Jon Mueller to ask if there was nonetheless area within the sulfation difficulty of Essays in Biochemistry – there was, so with Dulce we set about knocking their evaluation into the form of a assessment. The consequence was the third assessment which gives a new mannequin to elucidate the phenotypes that consequence from genetic variation within the genes encoding the enzymes and transporters concerned in heparan sulfate proteoglycan biosynthesis.
Evaluations at Essays in Biochemistry are subjected to see assessment, and for all three of those critiques the feedback had been each incisive and helpful, permitting us to enhance the articles. So a thanks to the reviewers for taking the time to learn our submissions and supply us with the advantage of your concepts and insights. One other nice plus is that Portland Press’ digital proofing system is a pleasure.
Evaluations do take a considerable effort, so now it’s time to return to these drafts of major analysis papers and end them!
